Guaitarilla was founded in 1536 by SEBASTIAN DE BELALCAZAR and Captain Francisco Hernandez Giron, by Act 28 of June 8, 1846 GUAITARRILLA falls within the province of Tuquerres.
In 1849, the chamber created the district Túquerres Guaitarilla and pointed as head of population of the same name, it is believed that the name comes from Guaitarilla Guaitara River, which means we must search the Quechua and Aymara language of the Incas of Peru, which means flower basket
Guaitarilla wrote a major historical site in the first year of the nineteenth century in May 1800, shared with Tuquerres being the centers of colonial indigenous insurrection against the abuses of the Rodrigues brothers clavijo, this was a spontaneous popular uprising.